Microglia, often referred to as the nervous system’s immune cells, monitor neuronal health. They are activated by neuronal injury or infection to produce pro-inflammatory factors (M1 phenotype ...

Ncardia’s iPSC-derived microglia may aid ALS research and help to screen new therapies that target inflammation in ALS.

leading to the activation of A1 astrocytes and M1 microglia and elevated neuroinflammatory cytokines. The disruption of this crosstalk between IL-3 and IL-3Rα induces lipid metabolic ...