The question of putative mechanisms of action continues to haunt psychopharmacology. Put simply, we know these drugs work, but we have very little idea how. We make guesses based on the ...

The SARS-CoV-2 pandemic interrupted much respiratory research. Respiratory clinical academics joined colleagues in providing clinical care, and global research efforts were directed to finding new ...

Knowledge of a drug's mechanism of action enables better dosing through monitoring of the drug's effects on the target pathway in the patient. For example, the proper statin dosage for a given ...

Discover how small biotechs are innovating in the weight loss therapy market with new treatments targeting unique mechanisms ...

In a review published in the Journal of Dermatologic Science and Cosmetic Technology, two Chinese researchers looked into the mechanism of action of preservatives in cosmetics. Co-author Zhenyu ...

The catalytic site of chymotrypsin contains an interior aspartic acid hydrogen-bonded to a histidine which in its turn is hydrogen-bonded to a serine. Polarization of the system due to the buried ...

This cellular effect of antithrombin is very similar to that of HRG, which has the same CLEC1A as its receptor, suggesting a completely new functional role and mechanism of action for this plasma ...

The FDA approved 16 psychiatric drugs over the last decade, most of which shared similar mechanisms of action with previously ...

and an effective treatment for an associated arthritis condition called spondyloarthritis (SpA), sulfasalazine's mechanism of action has been unclear. Now researchers at the Jill Roberts Center ...

Even though there are indications of the health-promoting and cell-protective properties of ergothioneine, the underlying mechanism of action was previously unknown. "Our analyses now finally ...