Abnormal accumulation of the amyloid-β peptide (Aβ ... in hAPP/TGF-β1 mice was associated with a strong activation of microglia and an increase in inflammatory mediators.

Scientists provide new evidence that preventing brain inflammation is a promising approach for the treatment of Alzheimer's disease. Their findings, based on studies in cell culture, mice and tissue ...

Resolving the complex role of microglia in AD development has the potential to lead to improved therapeutic approaches. Alzheimer’s disease is partially characterized by the formation of extracellular ...

Scientists from DZNE, University Hospital Bonn (UKB) and the University of Bonn provide new evidence that preventing brain inflammation is a promising approach for the treatment of Alzheimer's disease ...

Researchers at Nanyang Technological University in Singapore have made an important discovery that could lead to new ...

Transcriptomics-based research has shown that astrocytes, microglia, and oligodendrocytes ... such as the genes that code for beta-secretase, amyloid precursor protein, and various components ...

Reference: Jacquet RG, González Ibáñez F, Picard K, et al. Microglia degrade Alzheimer’s amyloid-beta deposits extracellularly via digestive exophagy. Cell Rep. 2024;43(12):115052. doi: ...

because defective microglia contribute significantly to brain inflammation and accumulation of amyloid beta plaques that are characteristic of the disease. Alzheimer’s is the most common form of ...

New research uncovers how declining protein clearance mechanisms with age lead to Alzheimer’s, Parkinson’s, and other ...

The Chandel Lab team, surprisingly, found a decrease in hippocampal amyloid-beta plaque deposition, and increased interactions between the microglia and amyloid-beta plaques in mice with ...

including tau and amyloid, Alzheimer's disease disrupts nerve cell communication and causes progressive brain abnormalities that lead to neuronal damage and ultimately to death. Microglia ...