Specifically, the toll-like receptor 4 appears to be a site at which drugs of abuse activate microglia. Toll-like receptor 4 activation consequently ... However, a growing body of evidence ...

The study, published in the journal Neuron, highlights microglia, the brain's primary immune cells, as central players in both the protective and harmful responses associated with the disease.

Microglia’s stress response drives toxic lipid production linked to Alzheimer’s progression. Blocking stress or lipid pathways reversed synapse loss in preclinical Alzheimer’s models. Findings ...

During development, there are known sex-related differences in how microglia function. But into adulthood, there was thought to be less variation in how they behave. Microglia maintain neuronal ...