Additionally, previous work in both obese mice and humans has also shown that microglia within the hypothalamus increase following high-fat feeding, prompting inflammation, the authors write in their ...

Those strongly affected included microglia and border-associated macrophages ... function and the increase in inflammation in the hypothalamus. The most significant gene expression changes ...

The researchers noted that acute benzene exposure triggers hypothalamic insulin resistance ... Genetic ablation of this pathway in microglia, rescued metabolic phenotype in benzene-exposed mice.