The nucleation of microtubules is primarily facilitated by the gamma-tubulin ring complex (γ-TuRC), which serves as a template for microtubule assembly. Recent research has focused on ...

γ-TuRC starting the nucleation process (left) vs. γ-TuRC closing (right). Once closed, thhe foundation is set and tubulins can be added to make the bridge as long as necessary ...

which enables efficient microtubule nucleation. Without this activation, the γTuRC would remain in its asymmetric form, which ...

which enables efficient microtubule nucleation. Without this activation, the γTuRC would remain in its asymmetric form, which ...

After nucleation of a daughter microtubule, Msd1-Wdr8 stabilizes the base of the Y-shaped nucleation structure and then recruit katanin (red) to sever the basal end of the daughter microtubule.

The complex of Nedd1 and γ-tubulin together localizes to the centrosome and enhances the microtubule nucleation around the centrosome.