The mouse had a raised, ulcerated mass on the flank of its right hind limb that measured 2.0 cm × 2.5 cm (Fig. 1). The lesion was first observed 15 d previously and had grown rapidly ...

“[This] mouse has just this amazing, intriguing phenotype of increasing bone mineral density ... Microcomputed tomography of the femurs of middle-aged, Notch-deficient mice revealed an increase in ...

Furthermore, when they injected the mouse version of the protein into wild type mice, the mice developed increased bone mass. CCN3 not only improved bone health in healthy mice but also spurred bone ...

Using genetically modified mouse models, including single and double knockout (KO) mice, the team investigated how the absence of these proteoglycans affects bone mass, water retention ...