New therapies to blunt this process include targeting enzymes below the cell membrane that serve as strategic nodes for hypertrophy regulation. Rho kinase (ROCK) is activated in cardiac ...

Cardiac hypertrophy is the abnormal enlargement, or thickening, of the heart muscle, resulting from increases in cardiomyocyte size and changes in other heart muscle components, such as ...

Hypertrophic cardiomyopathy (HCM) is a genetic disease characterized by abnormal myocardial hypertrophy, which can lead to a wide clinical spectrum, including sudden cardiac death and heart failure.

Another active area of research in the laboratory focuses on unraveling the mechanisms behind maladaptive, or pathological, and adaptive, or physiological, cardiac hypertrophy. In response to certain ...

HCM is typically characterized by asymmetric myocardial hypertrophy, which is often associated with diastolic dysfunction, LV outflow tract obstruction and mitral regurgitation. Myocardial cell ...

多项报道和研究者前期的工作已经证实，心肌肥厚时，亚硝基谷胱甘肽还原酶（S-nitrosoglutathione reductase, GSNOR）表达降低，导致多种蛋白质SNO修饰水平升高，促进心肌肥厚和心衰。但是GSNOR在心肌肥厚中下调的具体原因及干预手段仍不清楚。

High-intensity exercise raises sudden cardiac death risk in young hypertrophic cardiomyopathy patients, independent of ...

Aim Differentiating physiological cardiac hypertrophy from pathology is challenging when the athlete presents with extreme anthropometry. While upper normal limits exist for maximal left ventricular ...

The study links exertional heat stroke to chronic disorders, revealing impacts on body mass regulation and heart health, ...

Cardiovascular system Cardiac hypertrophy; increased stroke volume (SV); decrease in resting heart rate (HR); increase in maximum cardiac output (Q); capillarisation at the lungs and muscles ...

The following is a summary of “Role of glucocorticoid receptor expression in Chronic Chagas Cardiomyopathy: implications for ...