Animal studies suggest that various adverse consequences of smoking are primarily due to the pharmacological actions of nicotine through acetylcholinergic nicotinic receptor activation.

Tests with receptor antagonists indicated that these drug effects are mediated by central, but not peripheral, nicotinic receptors. There was an age-related decline in self-administration of nic ...

Miwa’s initial work showed that lynx1 was concentrated in the nervous system. Additional studies in collaboration with Ibañez-Tallon showed that lynx-1 altered the function of nicotinic acetylcholine ...

To understand at the molecular level how genetic variability, particularly with respect to nicotinic receptor genes, influences risk for drug dependence and co-morbid psychiatric disorders. Current ...

Nicotinic acetylcholine receptors play a crucial role in this process. According to Moen, when these receptors behave ...

Nicotine, a major component of tobacco smoke, could exert either nonreceptor-mediated biological effects or, more importantly, act on the different subtypes of nicotinic brain receptors ...

who studies nicotinic receptors at the University of Chicago. But an epibatidine-related compound tested by Abbott Labs as an analgesic in the late 2000s caused uncontrollable vomiting, McGehee says.