Nitric oxide synthase (NOS) generates NO in cells to regulate a vast variety of physiological functions. The bioactivity of NO is acutely terminated by its rapid oxidation to nitrite and nitrate.

Here we show that HDL stimulates endothelial nitric oxide synthase (eNOS) in cultured endothelial cells. In contrast, eNOS is not activated by purified forms of the major HDL apolipoproteins ApoA ...

The team’s experiments also revealed that SCAN’s activity depends on nitric oxide synthase (NOS), which generates the SNO-CoA cofactor. By elucidating SCAN’s mechanisms, the researchers have ...

Antioxidants within the formula support nitric oxide synthase production too. This is important because it protects against ...

It was this approach to science that led Professor Ignarro to discover how nitric oxide, a gaseous chemical in both the earth’s atmosphere and in human cells, could be used in medications to ...