Given the probable involvement of dendritic spines in synaptic plasticity and ... the likelihood of future seizures by disrupting the normal, finely-tuned balance between excitatory and inhibitory ...

of dendritic spines have been a topic of great interest over the last decade (reviewed in refs. 1–7). Such changes are of particular interest because these tiny protrusions are the normal site ...

It is reasonable to hypothesize that the same mechanisms that account for normal synaptic plasticity ... Structural abnormalities in dendrites (spine loss and dendritic beading) are commonly ...