it coordinates potentially dangerous steps in the base excision repair pathway. Figure 1: Schematic representation of single-nucleotide BER and alternatives for aborted intermediates. Recent ...

Three recent papers add support for the use of MMR genetic analysis in cancer diagnosis ... in single-strand scission and loading of the excision repair machinery, which leads to replacement ...

It will also highlight the fact that some DNA-repair-linked disorders show a mixed phenotype, including neurological symptoms, cancer disposition ... NER, nucleotide excision repair; pol η ...

Numerous anti-cancer drugs function by targeting the ... specifically those that operate a pathway called ...