it coordinates potentially dangerous steps in the base excision repair pathway. Figure 1: Schematic representation of single-nucleotide BER and alternatives for aborted intermediates. Recent ...

(A) Common DNA damaging agents (top), examples of DNA lesions induced by these agents (middle), and the most relevant DNA repair mechanism ... base- and nucleotide-excision repair, respectively ...

The disease provides a good model for understanding the mechanisms behind nucleotide excision repair: Patients with XP have mutations in bo The progress in nucleotide excision repair research could be ...

Efficient DNA repair mechanisms have evolved to ensure the ... xeroderma pigmentosum complementing protein B; NER, nucleotide excision repair; pol η, polymerase η; SSB, single-strand break ...

specifically those that operate a pathway called transcription-coupled nucleotide excision repair (TC-NER). TC-NER is a vital ...