Eflornithine irreversibly blocks ornithine decarboxylase (ODC), a key enzyme involved in cell division and proliferation associated with various types of cancer. It received orphan drug and ...

MiR-29b replacements also decreased PA200 association with proteasomes, reduced the proteasome’s peptidase activity and inhibited ornithine decarboxylase turnover, a proteasome substrate ...

p53 or degrons from ornithine decarboxylase. Proteasome inhibitors and stabilizing mutations in the target increase the intensity of the EGFP signal relative to the dsRed signal. Although in-depth ...