Our lab has had a long-standing interest in the role and regulation of the p53 tumor suppressor. Mutations in the p53 gene (TP53) are often associated with aggressive tumor behavior and poor patient ...

p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...

The ATM gene (mutated in the disease ataxia telangiectasia) activates the p53 tumor suppressor protein in response to DNA damage, explaining the higher incidence of cancer in AT patients.

All the various tp53 and Trp53 clones used in cancer studies came from transformed cell lines; they all contained mutations. Once researchers redefined p53 as a tumor suppressor gene and generated ...

A kidney cancer cell nucleus is studded with aberrant nuclear speckles (orange). Normal healthy cells tend to have the speckles clustered toward the middle. Image credit: Kate Alexander (Cold Spring ...

The p53 protein, is a tumor suppressor often inactivated in cancers by gene mutations or the inhibition by overexpressed MDM2 and MDM4(X). Pharmacological reactivation of wild-type p53 protein ...

Identification of genes inactivated by promoter CpG methylation is a powerful approach to discover novel tumor suppressor candidates. PCDH10suppresses gastric cancer cell growth through cell ...

p53 refers to the protein product of the TP53 gene. The traditional view of cancer development, driven by oncogene activation and tumor suppressor loss, has expanded to include genes involved in ...

P53 Overexpression and mutation seen in children ... clinical history of decreased tumor response to alkylators Lower expression compared with pediatric gliomas; better clinical history of ...