Study: The histamine pathway is a target to treat hepatic experimental erythropoietic protoporphyria ... of EPP- the Ferrochelatase mutant 1 with a pedigree from Pas (Fechm1Pas) mice and mice ...

Erythropoietic protoporphyria is a genetic disease in which ferrochelatase is defective. Protoporphyrin accumulates in erythrocytes, leaks into the plasma and results in severe skin photosensitivity.