Background The immune suppression mechanisms in pancreatic ductal adenocarcinoma (PDAC) remain unknown, but preclinical ...

IMC-002 is a fully human IgG monoclonal antibody designed to block CD47–SIRP-α interaction in order to promote the phagocytosis of cancer cells by macrophages. It binds to human CD47 with an ...

This study unveiled the role of Lrrk2 gene in regulating macrophage polarization and immune response. This finding provides ...

and CePA could effectively inhibit the phagocytosis of F4/80 labeled macrophages and improve the polarization of macrophages by inhibiting the activation of mTOR. In vivo experiments, the MASH ...