Both the pitavastatin molecule and the lactone metabolite undergo very little metabolism by CYP3A4 and, therefore, unlike some other statins, does not interact with CYP3A4 substrates. Pitavastatin ...

While, p-glycoprotein does not contribute to the bioelimination of pitavastatin, it is (as discussed previously) a substrate of OATP1B.

The work is a secondary analysis of the Phase III Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE), which demonstrated that the cholesterol-lowering medication pitavastatin reduced ...