It appears that there are two pathways of ... Unusually, the degradation of Rpn4 is largely ubiquitin independent, which highlights its function as a dedicated proteasome sensor and, furthermore ...

“It turns out that this pathway can be targeted ... the signal for it be destroyed by the proteasome. Although this revealed how pVHL marks HIF for degradation, how the interaction of the ...

C-terminal amidation is a PTM that involves the addition of an amid group to the C-terminus of a peptide or protein. Currently there is no direct evidence to suggest that C-terminal amidation of ...

mechanisms of an assembly-coupled degradation via an oncorpotein and assembly chaperone, Gankyrin in cancers, and (iii) signaling pathways for active disassembly of the proteasome via the chaperones ...