Proliferating cells, in particular tumor cells, express a dimeric isoenzyme of pyruvate kinase, termed Tumor M2 pyruvate kinase. In the last few years, much attention has been paid to this novel ...

What Is Pyruvate Kinase Deficiency? Pyruvate kinase deficiency is a condition in which red blood cells break down faster than they should. This can lead to anemia (not enough red blood cells). Most ...

SL1009 is expected to increase energy production by inhibiting pyruvate dehydrogenase kinase and stimulating residual pyruvate dehydrogenase complex activity. The NDA is supported by data from a ...

The purpose of this study was to investigate whether circulating pyruvate kinase M2 (PK‐M2) levels are elevated in the peripheral blood and to assess their association with diagnosis and prognosis in ...