Proliferating cells, in particular tumor cells, express a dimeric isoenzyme of pyruvate kinase, termed Tumor M2 pyruvate kinase. In the last few years, much attention has been paid to this novel ...

SL1009 is expected to increase energy production by inhibiting pyruvate dehydrogenase kinase and stimulating residual pyruvate dehydrogenase complex activity. The NDA is supported by data from a ...