Well-characterized domains are Ras nanoclusters that may have a crucial control in input–output relationships in the Ras–Raf–MAPK/ERK kinase–ERK pathway. Distinct spatial domains can also ...

Aberrant activation of the Ras/Raf/MAPK/ERK kinase/extracellular signal-regulated kinase cascade and the VEGF pathway are commonly observed in breast cancer cells leading to malignant cell ...

of the mitogen-activated protein kinase (MAPK) pathway, IMM-6-415, will be evaluated as an oral, twice-daily treatment. Patients with rapidly accelerated fibrosarcoma (RAF), kirsten rat sarcoma ...

NEW YORK – Immuneering on Thursday said it signed a clinical supply agreement with Regeneron to obtain the anti-PD-1 therapy Libtayo (cemiplimab) for a Phase IIa trial testing Immuneering's MEK ...

2006;2(4):180-181. The fact that PTC is associated with mutually exclusive alterations to MAPK pathway effectors offers intriguing therapeutic opportunities. Ras, RET and B-Raf are part of a ...

These included the mitogen-activated protein kinase kinase (MAP2K)/ mitogen-activated protein kinase kinase kinase (MAP3K)/ ...

Pasithea Therapeutics (KTTA) announced that the external Safety Review Committee recommended that the Company’s Phase 1 clinical trial of ...

Verastem Oncology (Nasdaq: VSTM), a biopharmaceutical company committed to advancing new medicines for patients with RAS/MAPK pathway-driven cancers, today announced that its management team will ...