Computational tool incorporates transcriptome size to improve RNA-seq analysis
Researchers studying gene expression have access to vast amounts of data from cells or tissues. This is thanks to advances in ...
Nature2 个月
The RNA sequencing revolution empowers all corners of biology
They ruled out using direct capture methods to prepare samples for RNA-seq, as chloroplast mRNAs are not typically polyadenylated. They had also previously encountered issues with probe-based rRNA ...
腾讯网13 天
Nature Methods | 单细胞多模态测序的未来：UDA-seq如何引领新革命？
引言近年来，单细胞RNA测序技术（scRNA-seq）在揭示复杂生物系统和探索遗传学及临床研究中取得了突破性进展。然而，仅依赖单一的转录组信息往往难以区分分子相似但功能差异显著的细胞类别。因此，融合多种模态信息的单细胞测序技术逐渐成为研究热点，通过同时获取单个细胞的多维数据，研究人员能够更全面地解析细胞状态及其 ...
RNA sequencing approach offers real-time and programmable transcriptome sequencing
Conventional targeted RNA-seq methods often require labor-intensive pre-sequencing enrichment steps, which can compromise ...
Computational tool extracting disease-specific drug response signatures could improve ...
A new computational tool could help researchers identify promising drug combinations for treating cancer, according to a new ...
eLife1 天
Single-cell sequencing provides clues about the developmental genetic basis of evolutionary ...
This study provides a valuable new resource to investigate the molecular basis of the particular features characterizing the pipefish embryo. The authors found both unique and shared gene expression ...
Baylor College of Medicine4 年
Chenghang Zong Lab
The lab focus on pancreatic cancer in particular. Development of Quantitative Single-cell RNA-seq methods for Studying Tumorigenesis and Aging processes The quantification of transcriptional variation ...
Novel study uncovers molecular basis of eosinophilic esophagitis food allergy
A multi-institutional study led by researchers at Children's Hospital of Philadelphia (CHOP) is the first to identify one of ...
technologynetworks4 个月
New Methods for RNA Modification Detection and Structure Probing
Recent advancements in next-generation sequencing technologies have provided powerful tools for RNA modification detection, yet these methods often lack the sensitivity and specificity needed to ...
NGS-Based RNA Sequencing Market To Surpass USD 12.1 Billion By 2032, Growing At A CAGR Of 17.1%
Rising demand for precision medicine & groundbreaking innovations in RNA sequencing drive growth in oncology, drug discovery, & personalized therapies. Akash Anand SNS Insider Pvt. Ltd 415-230-0044 ...
Baylor College of Medicine4 年
Hongjie Li
2017 Cell; Li et al 2020 Current Biology). Recently, we developed a single-nucleus RNA-seq method in flies (McLaughlin, …, Li, 2021 eLife) and applied it to the Fly Cell Atlas (FCA) project, a large ...