Researchers studying gene expression have access to vast amounts of data from cells or tissues. This is thanks to advances in ...

With a modified polymerase and optimized oligonucleotide chemistry, Helicos' single-molecule sequencer takes on RNA. RNA sequencing (RNA-seq) is actually a misnomer for the increasingly popular ...

Conventional targeted RNA-seq methods often require labor-intensive pre-sequencing enrichment steps, which can compromise ...

Researchers at the University of Toronto have invented a new method that uses DNA sequencing to measure metabolites. This ...

Researchers have developed a method to accurately assess the effect of specific drugs in isolated pancreatic tissue by using a refined single-cell RNA sequencing method. A new computational method for ...

Recent advancements in next-generation sequencing technologies have provided powerful tools for RNA modification detection, yet these methods often lack the sensitivity and specificity needed to ...

引言近年来，单细胞RNA测序技术（scRNA-seq）在揭示复杂生物系统和探索遗传学及临床研究中取得了突破性进展。然而，仅依赖单一的转录组信息往往难以区分分子相似但功能差异显著的细胞类别。因此，融合多种模态信息的单细胞测序技术逐渐成为研究热点，通过同时获取单个细胞的多维数据，研究人员能够更全面地解析细胞状态及其 ...

Long-read sequencing may be a better option for rare disease diagnosis than short-read sequencing, according to a recent ...