are in close association with the outer plasma membrane of the cell, and more particularly caveolae (Fig. 4A). This suggests that these receptor proteins can mediate both genomic as well as rapid ...

Cell membrane receptors are important therapeutic targets in many diseases, including cancer. The efficacy of targeted protein degraders of intracellular proteins, such as proteolysis-targeting ...

Thomas Sollner (University of Munich): "The complex organization of eucaryotic cells into various membrane-bound compartments (organelles) requires a very specific targeting of newly synthesized ...

Researchers have developed a computational method to explicitly consider the impact of water while designing membrane receptors with enhanced stability and signaling, paving the way for novel drug ...

Innovative designs of GPCRs with enhanced signaling and stability offer new insights for drug discovery and synthetic biology ...

EPFL researchers have developed a computational method to explicitly consider the impact of water while designing membrane receptors with enhanced ...

Engineered immune cells called CAR-T cells are used in the treatment of cancer. Researchers from Uppsala University have now ...

Adhesion G protein-coupled receptors (aGPCRs ... The extracellular region of an aGPCR extends from the cell membrane into space outside the cell, where it can bind to molecules and receptors ...

It has been a few years since AI began successfully tackling the challenge of predicting the three-dimensional structure of proteins, complex molecules that are essential for all life. Next-generation ...

that molecules had to cross the cell’s outer membrane in order to bind to them, he says. The researchers tested this hypothesis with a series of experiments. By tagging the serotonin 2A receptor with ...