Although most of the medical cognoscenti had reservations concerning the role of the renin–angiotensin system in human hypertension, I, along with Vane and a few other key individuals at Squibb ...

Renin–angiotensin system blockers are widely used to treat diabetic nephropathy, but compensatory renin release reduces their efficacy. Since vitamin D is known to repress renin gene ...

This review will highlight the major findings from these studies. The renin-angiotensin-aldosterone system has long been recognized as playing a major role in cardiovascular disease by its ...

Angiotensin II (AT-II)-Receptor Antagonists are Reviewed. Research focused on blocking the renin- angiotensin system (RAS) led to the discovery of angiotensin-converting-enzyme (ACE) inhibitors ...

On a Sunday afternoon in mid-April this year, Daniel Jacobson, a computational systems biologist at Oak Ridge National Laboratory in Tennessee, was looking at gene expression data from the lung fluid ...

Activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) occur in patients with systolic heart failure. Then mainstay of therapy for this disorder is ...

The class of drugs, known as renin–angiotensin system (RAS) inhibitors, block the effects of the renin enzyme, relaxing blood vessels and allowing blood to flow more easily. They are widely used ...