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生物通
16 天
PNAS | 中国科大高大兴、项晟祺课题组揭示cGAS动态相分离调控酶活的 ...
该研究主要探讨了cGAS蛋白的相变和酶活性的调控机制,通过综合运用生化、核磁共振(NMR)波谱学和细胞生物学等手段,我们揭示了cGAS的 N端无序区(IDR),如何精细调控cGAS的相变凝聚相的材料特性。具体而言,N端无序区的介入增强了相变颗粒的流动性和通透 ...
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