Purpose: The pharmacology, pharmacokinetics, clinical efficacy, adverse effects, drug interactions, and role in therapy of vildagliptin for the treatment of type 2 diabetes mellitus were reviewed.

Vildagliptin improves glycemic control by enhancing pancreatic islet function and could benefit this patient group. Fonseca et al. conducted a multicenter, double-blind, placebo-controlled study ...

Objective: We sought to evaluate the efficacy and safety of vildagliptin, a new dipeptidyl peptidase-4 inhibitor, added to metformin during 24 weeks of treatment in patients with type 2 diabetes.