The use of B-cell targeted therapies for the treatment of systemic lupus erythematosus (SLE) has generated great interest owing to the multiple pathogenic roles carried out by B cells in this disease.

Materials and methods Peripheral blood B cells from six healthy donors (HDs) and six systemic lupus erythematosus (SLE) patients were stimulated by CD40 and TLR9. Peripheral blood monocytes were ...

Transcriptomic analysis identifies an interferon (IFN) gene signature in transitional B cells in the SLE BM, but surprisingly also in the BM PC derived from SLE. BM PC and B cells phosphorylate STAT1 ...

pDCs are considered the primary source of IFN-α, which, as will be discussed below, makes them potentially very relevant to the immunopathology of SLE ... control B-cell proliferation ...

Methods We used gene set variation analysis with multiple IGS encompassing the response to both type 1 and type 2 IFN in isolated CD14+ monocytes, CD19+B cells, CD4+T cells and Natural Killer (NK) ...