We therefore set out to try to elucidate the mechanism of action of compactin and the ... by a new statin with an extra methyl group—simvastatin (Fig. 2). Sankyo, in turn, developed pravastatin ...

Although their main mechanism of action is lowering of LDL-C, statins may also contribute to lower ASCVD rates via other mechanisms, including stabilization of atherosclerotic plaques as well as ...

"Understanding how statins benefit this population could lead to additional and more targeted therapies to protect their cardiovascular health." The work is a secondary analysis of the Phase III ...