Single-strand breaks generated during DNA repair were observed converting to double-strand breaks and reversibly switching between states in response to oxidation in cultured neurons as well as in ...

(A single colony arises from one cell going ... Singh, R. K. & Krishna, M. DNA strand breaks signal the induction of DNA double-strand break repair in Saccharomyces cerevisiae.

The newly synthesized DNA ... chromosome (break-induced replication; BIR). If two homologous regions flank the DSB, they can anneal after being exposed by DNA resection (single-strand annealing ...

APOBEC enzymes, which normally help fight viral infections by mutating viral DNA, cause repeat expansions and are unusually ...

Efficient DNA repair mechanisms have evolved to ensure ... polymerase η; SSB, single-strand break; TCR, transcription-coupled repair. Abbreviations: BER, base excision repair; DSB, double-stand ...

These mechanisms can detect and correct different types of DNA damage, such as base mismatches, single-strand breaks, and double-strand breaks. DNA repair is essential for preventing the accumulation ...

RecA is a bacterial protein that is crucial for repairing double-stranded breaks in DNA via the process of homologous recombination. RecA binds to single-stranded DNA, searches along a separate piece ...

The first enzyme in the BER pathway, called MPG, excises not the entire nucleotide but only the base part of it, creating an abasic site, which is converted into a single-strand DNA break by ...

Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

In contrast, systems that use modified or catalytically impaired Cas proteins are less active and only introduce single-strand breaks, or nicks, in the DNA. Base editing is a genome editing system ...