The landmark Randomized Aldactone Evaluation Study (RALES), published in 1999, showed that spironolactone, a potassium-sparing diuretic, improves outcomes in patients with severe heart failure.

Spironolactone is a medication usually used for fluid retention, but doctors sometimes use it to treat androgenetic alopecia, a type of hair loss in females. Spironolactone (Aldactone) is a type ...

investigated whether adding the aldosterone receptor antagonist spironolactone to renin–angiotensin system inhibition improved proteinuria in patients with diabetic nephropathy. Patients with ...