The translational machinery already present in the cell then carries on its usual business of assembling the protein, incorporating the unnatural amino acid when it reads the reassigned stop codon.

The method described here should be generally applicable to other stem cells for non-natural amino acid incorporation, and to the study of many other membrane proteins that are difficult to be studied ...

Select the journal/section where you want your idea to be submitted: The site-specific incorporation of unnatural ... protein-based scaffolds. Research on reprogrammed protein translation has now ...

Getting the cell to incorporate the conjugate during protein synthesis could improve the yield compared to chemically altering ready-made antibodies, he explained. Researchers could also use this ...

In this work, we present the discovery of a novel type of chirality—staircase chirality as inspired by the design and synthesis of unnatural amino acid derivatives. The architecture of staircase ...

Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

Incorporating the amino acid building block proline into the nascent protein molecule presents ... the metabolism of the cell influences the activity of EfpL." It is particularly interesting ...