Nature Chemical Biology - Excitatory synapses are located in confined chemical spaces called the dendritic spines. These are atypical femtoliter-order microdomains where the behavior of even single ...

An electrical impulse cannot directly cross the gap so a different mechanism has to be used. Between impulses the transmitter molecules are rapidly removed from the synaptic cleft to prevent ...

When naive T cells encounter antigen-presenting cells (APCs), membrane and cytoplasmic molecules rearrange at the T cell–APC contact area to form the immune synapse. Finetti et al. now reveal an ...

New research reveals how electrical synapses filter sensory input, helping animals choose actions based on context.

Researchers analyzed the genetic connection of retinal cells and several neuropsychiatric disorders. By combining different ...

A multi-disciplinary team has found that depriving lab mice of sleep can lead to a reduction in synapse diversity in the brain. In their study, published on the open-access site Current Biology ...