Furthermore, we currently have little understanding of the functional states of synapses on a cell-assembly basis. What is the overall signaling impact of synaptic inputs at physically non ...

B cells are now reported, in a recent paper in Nature, to have their own immunological synapses with APCs. Only this time the antigen is whole and B cells don't keep it to themselves.

Dr. Roddy O'Connor explores "hit & run" serial killing in CAR T cells, discussing how metabolic reprogramming influences ...

An electrical impulse cannot directly cross the gap so a different mechanism has to be used. Between impulses the transmitter molecules are rapidly removed from the synaptic cleft to prevent ...

Then, in the 1940s, Canadian psychologist Donald Hebb proposed that, when neurons encoded memories, connections, called synapses, between coactivated memory, or engram, cells were strengthened—a ...

However, a series of weak stimuli can combine, increasing the amount of neurotransmitter that is released. This results in enough neurotransmitter being diffused across the synaptic cleft to ...

Scientists have uncovered a crucial pathway that links brain cell activity to the activation of genes responsible for ...

To understand how these brain cells exchange information through their synapses (junctions to exchange chemical 'messages'), the team of Prof. Joris de Wit (VIB-KU Leuven Center for Brain and ...

A recent study has uncovered key insights into the differing tumour rejection behaviours of chimeric antigen receptor T cells ...

Molecular dynamics at immune synapse lipid rafts influence the cytolytic behavior of CAR T cells. Science Advances , 2025; 11 (2) DOI: 10.1126/sciadv.adq8114 Cite This Page : ...

Ahmed Gad, postdoctoral associate in Ahmed's lab, the research team examined molecular dynamics at the immune synapse. The team biopsied the CAR T cell immunological synapse by isolating the ...