In 1994, a nucleic acid-binding protein was found ... in myofiber injury in IBM. “TDP-43 redistribution has the potential to alter normal translation of RNA or normal function of microRNAs ...

The TDP-43 protein is a key factor in nervous system function and neuronal plasticity. It is a DNA- and RNA-binding protein that regulates gene expression, and its dysfunction has been associated ...

Binding of both the RNA-binding protein TDP-43 and the m6A RNA modification chemical tag has been found to be altered on genes that are dysregulated in HD. Further, TDP-43 pathology, classically ...

Binding of both the RNA-binding protein TDP-43 and the m6A RNA modification chemical tag has been found to be altered in genes that are dysregulated in HD. Further, TDP-43 pathology, classically ...

The biomarker locates a protein associated with the loss of function for the TDP-43 protein (seen as a molecular model in this image), an abnormality linked to people who develop ALS or FTD.