【导读】TREM2是一种主要在髓样细胞表面表达的受体，是病理诱导免疫信号传导中的一个主要枢纽基因。然而，其在肝细胞癌（HCC）中的功能仍存在争议。1月21日，新疆石河子大学研究团队在期刊《Journal of Experimental & ...

TGF-β1 and COX-2 are gatekeeper targets for oncology ... marked tumor regression through extra penetration of CD4 and CD8 positive T cells (Fig. 1). Immunohistochemistry showed the T cells ...

Secreting CXCLs, ILs, TGF-β, CCL12, PGE2, CAFs promote pro-cancer macrophage conversion, inactivate NK cells, and hinder CD8+T cell aggregation. Immune cells like TAMs, NKs, CD8+Ts, MCs ...