For example, how is NCoR recruited to or cleared from TLR4-responsive genes ... are both markedly upregulated by TLR signalling in macrophages 35, which indicates that these factors might have ...

LPS, also known as endotoxin, is a molecule found in the outer membrane of many different types of bacteria. Through its interaction with TLR4, LPS induces a strong inflammatory reaction in humans.

Our hypothesis is that exposure to particulate matter containing heavy metals (Cd, As and Mn) leads to induction and activation of peptidyl arginine deiminase 2 (PAD2) in lung macrophages and ...