The discovery of the nuclear receptor PPAR-γ as the molecular target of TZDs suggested a mechanism for their beneficial effects on insulin action. As PPAR-γ is mainly expressed in fat cells ...

Thiazolidinediones (TZDs) are the major drug class used to improve insulin sensitivity in the treatment of type 2 diabetes. However, TZDs have several adverse effects, including weight gain and ...

Am J Health Syst Pharm. 2007;64(9):931-936. These favorable effects on cardiovascular surrogate endpoints highlight the TZDs' potential to affect the progression of diabetes and cardiovascular ...