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Understanding iron overload in β-thalassemia: Mechanisms, diagnosis, and treatmentsβ-Thalassemia is a genetic disorder characterized ... through iron-mediated Fenton reactions, contributing to oxidative stress and tissue damage. Chronic iron overload is particularly detrimental ...
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Glutamine metabolic switch is key to red blood cell development and disease, researchers revealRed blood cell maturation depends on heme production, but ammonium (a byproduct of heme production) can accumulate if not removed, causing oxidative stress ... such as β-thalassemia, because ...
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