The complement system is an important part of the humoral ... as well as expose and activate the thioester moiety for covalent attachment to target surfaces. The activity of the surface-bound ...

Researchers discovered a previously unknown mechanism that may drive tissue damage and a new target for drug discovery.

Our immune system is armed with an array of defenses designed to detect and eliminate harmful threats. One of its most powerful defense mechanisms is the complement system—a group of proteins that ...

Our immune system is armed with an array of defenses designed to detect and eliminate harmful threats. One of its most powerful defense mechanisms is ...

IgG activates complement ... the central component of the complement system C3, or all four FcγRs combined with C3. We show that absence of IgG effector pathways rather deteriorates than improves ...