Researchers have revolutionized cancer immunotherapy by developing a way to grow T cells in the lab that live longer and ...

近日，上海交通大学医学院附属仁济医院心内科卜军课题组在《Nature Immunology》发表了研究论文“Integrating single-cell RNA and T cell/B cell receptor sequencing with mass cytometry reveals dynamic trajectories of human peripheral immune ...

Researchers have identified a method to enhance the effectiveness of a promising cancer treatment. They found that modifying ...

A new way to grow T cells in the lab enables them to live longer and better destroy cancer cells in a mouse model of melanoma ...

Engineered immune cells called CAR-T cells are used in the treatment of cancer. Researchers from Uppsala University have now ...

Findings indicate that altering glucose metabolism in T cells boosts their therapeutic potential against melanoma, paving the way for improved immunotherapies.

在细胞工程领域，分离经过基因编辑的细胞一直是研究热点，目前已开发出多种方法。如使用表面标签和耐药盒来富集含有转基因整合的细胞，但对细胞进行多种药物处理或连续进行阳性选择会对细胞活力、性能和产量产生负面影响；靶向必需位点虽可富集转基因整合细胞，但同时编辑多个必需基因的后果尚未明确；还有研究利用在一个位点引入的选择标记来富集另一个位点的整合，但缺乏直接多标记选择的富集方法，难以获得更纯的细胞群体。

Within a large group of more than 700 patients treated with CAR T cell therapy, researchers found no evidence that the therapy itself caused any type of secondary cancer in the modified T cells, ...