The discovery of RNAi dates back to the 1990s when researchers observed unexpected gene silencing in plants and fungi. In 1998, Andrew Fire and Craig Mello published a groundbreaking study ...

In 2002, on the heels of the discovery that RNA interference existed in human cells, the usually reserved journal Science proclaimed RNAi the "breakthrough of the year." Here was a part of the ...

Using RNA to interfere with a gene’s expression of disease-causing proteins is a validated therapeutic approach, but so far, the products in this drug class only address liver proteins.

RNA interference (RNAi) therapeutics silence genes, disrupting the production of proteins that contribute to disease. Scientists at Alnylam Pharmaceuticals have developed and are testing multiple RNAi ...

The most recent addition to the methods hall of fame is RNA interference (RNAi). The discovery of a whole universe of small RNAs with regulatory functions of fundamental importance was entirely ...

View Full Profile. Learn about our Editorial Policies. The natural RNAi mechanism can be directed by either short interfering RNA (siRNA) or microRNA (miRNA). 1 There are four key steps in the RNAi ...

The more researchers examine RNA, the more surprises they continue to uncover. What have we learned about RNA structure and function so far? Although RNA is a single-stranded molecule, researchers ...

RNA, or ribonucleic acid, is a essential biological molecule that plays a crucial role in various cellular processes. It is a polymeric molecule composed of nucleotides, each containing a ribose sugar ...

For discussion questions and lesson plans, go to the RNA Lab collection on PBS LearningMedia. The standards-based NOVA RNA Lab allows users to explore the science of RNA and learn how to design ...