During beta-oxidation, fatty acid molecules are broken down by removing two-carbon units from the carboxyl end of a fatty acid molecule to produce acetyl-CoA.

These observations led to the discovery of acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS), the ... and its malonyl CoA product regulates fatty acid entry into the mitochondria for their ...

The absence of PanK4 led to a significant increase in acetyl-CoA, which disrupted the regulation of fatty acid oxidation and glucose metabolism. During training studies with mice specifically ...