From being a promising yet underexplored approach in the 1990s, mRNA therapeutics have evolved dramatically. The discovery of ...

Enzymes are a vital tool that make in vitro transcription possible and refine the reaction products to generate highly pure, homogeneous mRNA. In this ebook, we provide in-depth review into ...

New therapeutic possibilities for various diseases are made possible via mRNA. The adaptability of in vitro transcribed (IVT) mRNA is largely due to its simpler cell-free manufacture, cell cycle ...

Messenger RNA abundance is determined by balancing transcription and RNA decay. mRNA stability can be rapidly modulated to alter the expression of specific genes thereby providing flexibility in ...

The importance of in vitro transcription as a component of the mRNA therapeutic manufacturing workflow has grown significantly in recent years. The in-process raw materials for synthetic mRNA ...

“Larger mRNA-based therapeutics are synthesised by in vitro transcription, which is not amenable to extensive nucleotide modifications and thus have poor stability when administered into the bod ...

Quality control (QC) is vital to the in vitro transcription (IVT) RNA workflow. Because IVT RNA synthesis generates RNA that scientists use in multiple downstream applications, it is critical to start ...

InDevR partners with Aldevron to describe how the VaxArray 5′CapQ assay can be used to measure intact mRNA in a single assay to streamline bioprocess development.

templates for in vitro transcription (IVT) synthesis of mRNA molecules. Alchemy cell-free DNA technology is now available at research grade, providing researchers with a faster, more efficient ...

continuous flow RNA in vitro transcription (IVT) and purification system that brings cost effective and scalable RNA manufacturing to the market. Traditional RNA production methods are costly and ...