The past few decades have seen growing interest in the neuropsychiatric syndrome of apathy, conceptualised as a loss of motivation manifesting as a reduction of goal-directed behaviour. Apathy occurs ...

Objectives We aimed to identify existing outcome measures for functional neurological disorder (FND), to inform the development of recommendations and to guide future research on FND outcomes. Methods ...

3 UK Dementia Research Institute at Edinburgh, The University of Edinburgh, Edinburgh, UK 4 The Usher Institute, The University of Edinburgh, Edinburgh, UK Background Inflammatory responses to ...

2 NIHR Biomedical Research Centre, Guy's & St. Thomas’ NHS Foundation Trust and King's College London, London, UK 3 Farr Institute of Health Informatics, University College London, London, UK 4 ...

OBJECTIVES Increased resistance to stretch of muscles after stroke may be the result of centrally mediated neural factors such as spasticity or local, peripheral factors such as muscle contracture or ...

Background Total bilirubin (TBIL) has antioxidant and anti-inflammatory properties. This study aimed to determine whether elevated TBIL could modify the association between diabetes and stroke. Method ...

Cyclotron Research Centre, University of Liège, Sart Tilman, 4000 Liège, Belgium Institute of Cognitive Neurology, University College London, Alexandra House, 17 Queens Square, London WC1N3AR, England ...

Objective Persistent difficulty in using the upper limb remains a major contributor to physical disability post-stroke. There is a nihilistic view about what clinically relevant changes are possible ...

Objective To test the hypothesis that imaging signs of ‘brain frailty’ and acute ischaemia predict clinical outcomes and symptomatic intracranial haemorrhage (sICH) after thrombolysis for acute ...

Background Biological ageing is one of the principal risk factors for neurodegenerative diseases. It is becoming increasingly clear that acceleration of DNA methylation age, as measured by the ...

Psychogenic non-epileptic seizures (PNES) represent a diagnostic challenge. When trying to distinguish between PNES and epileptic seizures (ES), clinicians rely on the presence or absence of several ...