Results of a multinational genetic study suggest that defects in transfer RNA (tRNA) processing may be responsible for many cases of the neurodegenerative disease pontocerebellar hypoplasia (PCH).

tRNAs are highly conserved across all domains of life, from bacteria to archaea and eukaryotes. This evolutionary conservation highlights the fundamental role of tRNA in the essential process of ...

In this study, we have found that high levels of RTP801 interfere with the tRNA ligase complex, which is responsible for RNA processing, specifically in the process of ligation of its exons ...

Why should we care about tRNA modification? Transfer RNA (tRNA) is at the heart of translation — the process at which the genetic code of an organism is deciphered into functional machines, i.e.

Here's how anticodons facilitate the translation process: The specificity of the anticodon-codon interaction ensures that ... Wobble base pairing enables a single tRNA molecule to recognize multiple ...

The researchers discovered how one enzyme uses another's structure as a scaffold to recognize and efficiently process these ...