迄今为止，大多数基于 CRISPR 的基因编辑疗法依赖于以下三种 Cas 核酸酶之一：化脓链球菌 Cas9 （SpCas9）、金黄色葡萄球菌 Cas9 （SaCas9）和氨基酸球菌 ...

Cas9, the first Cas protein repurposed for cutting DNA, introduces double-strand breaks that recruit DNA repair machinery. Despite its successes, the CRISPR-Cas9 system has several limitations, ...

This study presents an optimized CRISPR-Cas12a system for large-scale genetic screening, revealing critical genes involved in lymphoma development and therapy.

Australian researchers have successfully introduced an improved version of Cas12a gene-editing enzyme in mice.

In addition, some companies are using CRISPR for screening (which shouldn't be confused with genetic testing). With CRISPR screening, genes are edited in a way that makes them inoperative.

Monoallelic loss of PTEN and ARID1A is identified in normal colonic epithelium. The resulting haploinsufficient phenotypes ...

CRISPR-Cas9 gene editing relies on a guide RNA that binds to a desired DNA sequence and ... Base and prime editing also spawn undesired effects that can only be spotted with scrupulous screening. “As ...

CRISPR Therapeutics AG is a gene editing company, which engages in the development of transformative gene-based medicines for serious diseases using its proprietary CRISPR/Cas9 platform.

It's clear though that these companies need time. Even with the only approved CAS9 based treatment out there, CRISPR is still years away from achieving its potential. In a recent update to ...

This streamlined licensing option enables a broader spectrum of innovators to access CRISPR/Cas9 intellectual property ... high-throughput screening and functional genomics. Prof Emmanuelle ...