Adenosine receptors are G protein-coupled receptors that mediate the effects of adenosine, a purine nucleoside. There are four main types: A1, A2A, A2B, and A3, each with specific functions and tissue ...

The activation of the adenosine A2A receptor, which is mediated by the inhibition of adenosine A1 receptor, has been associated with depression-like behavior and anhedonia. High levels of cortisol, ...

Exploration of adenosine mechanism revealed adenosine receptors as a potentially useful target of therapy in RA.

Caffeine blocks physiological intracellular Ca 2+ oscillations by inhibition of inositol 1,4,5-trisphosphate receptor-(IP 3 R)-mediated signalling ... Neither specific phosphodiesterase inhibitors nor ...

School of Pharmaceutical Sciences, University of Geneva, 1206 Geneva, Switzerland Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva ...

Sleep's role to down-scale glutamate, excitatory, frontal cortical synapses is extended to include an up-scaling of metaplastic LTP potential, in recovery from prolonged waking induced saturation of ...

A 2023 report from the National Coffee Association found that 63% of Americans drink coffee every day. According to recent surveys, the ...

Transient receptor potential (TRP) channels are a superfamily of non-selective cation channels that act as polymodal sensors in many tissues throughout mammalian organisms. In the context of ion ...

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