Many challenges remain in the preclinical evaluation, adjudication, and prioritization of novel compounds in therapeutic discovery pipelines. These obstacles are evident by the large number of ...

Evidence for a final common pathway for disorders of the myocardium (pages 246 and 320–330). These studies further our understanding of the heart in health and disease, particularly in the ...

The CMs within the microtissues begin spontaneous beating within a few days and mature over 21 days, displaying structural and functional properties of mature CMs including sarcomere organization, ...